Analysis of Case-Parent Trios Using a Loglinear Model with Adjustment for Transmission Ratio Distortion
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چکیده
منابع مشابه
Analysis of Case-Parent Trios Using a Loglinear Model with Adjustment for Transmission Ratio Distortion
Transmission of the two parental alleles to offspring deviating from the Mendelian ratio is termed Transmission Ratio Distortion (TRD), occurs throughout gametic and embryonic development. TRD has been well-studied in animals, but remains largely unknown in humans. The Transmission Disequilibrium Test (TDT) was first proposed to test for association and linkage in case-trios (affected offspring...
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The transmission disequilibrium test (TDT) customarily uses affected children and their parents (often case-parent trios, TDTD). Control-parent trios are necessary to guard against spurious significant results due to segregation distortion but are not generally utilized in the identification of disease susceptibility loci (DSL). Controls are often easy to recruit and the TDT can easily be exten...
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ژورنال
عنوان ژورنال: Frontiers in Genetics
سال: 2016
ISSN: 1664-8021
DOI: 10.3389/fgene.2016.00155